Immunology/Oncology Stem Cell Scientist
iPSC, ES, HSC, UCB
CRISPR, TALEN, KO, KI
Non-viral Gene Delivery
Bispecific Antibodies
Tumor Microenvironment
NK Cell Cross-talk
Genome edited stem cell therapy: CRISPR/TALEN genome editing in iPSCs. Model establishment for off-the-shelf cell therapy. Non-viral gene-editing in iPSCs.
Making “off the shelf” blood cells: Epigenetically modulated ESC/iPSCs enhanced expansion of hematopoietic stem cells and increased efficacy of bone marrow transplantation, which can differentiate to multi-lineage blood cells including NK cells.
NK cell therapy in tumor microenvironmet: Defining genes and subtypes of tumor infiltrating NK cells by RNA-seq and etc. for NK cell therapy: which can be used for NK-CAR.
Understanding trajectory of ILCs : Identifying innate lymphocyte cells’(ILC) trajectory after making epigenetic regulation of ES/iPS derived HSC
Therapeutic antibody project
Bi-specific antibody project
Cell penetrating protein project
Thesis: “Combining gene therapy using conditionally replicating adenovirus (CRAd) and ad-TRAIL in head and neck cancer cell lines.”
Thesis: “The role of STAT1 in tumor killing induced by STAT3 inhibition of head and neck carcinoma cell lines”
Seonhui Shim, Renee Woods, Tyler Shank, Ashley M. Yingst, Dejene M. Tufa, Kenneth Jones, Michael R. Verneris.
Accepted in Stem cell Translational Medicine.
Dejene M. Tufa, Tyler Shank, Ashley M. Yingst, George Devon Trahan, Seonhui Shim, Jessica Lake, Renee Woods, Kenneth Jones and Michael R. Verneris.
2020 Science Immunology
Dejene M. Tufa, Tyler Shank, Ashley M. Yingst, George Devon Trahan, Seonhui Shim, Jessica Lake, Renee Woods, Kenneth Jones and Michael R. Verneris.
2020 Scientific Reports
Dejene M. Tufa, Ashley M. Yingst, Tyler Shank, Seonhui Shim, Jessica Lake, Renee Woods, Kenneth Jones and Michael R. Verneris.
2019 Frontier immunology
Dejene M. Tufa, Ashley M. Yingst, Tyler Shank, Seonhui Shim, Jessica Lake, Renee Woods, Michael R. Verneris.
Frontiers Immunology 2019 March
Mathew G. Angelos, Paige N. Ruh, Beau R. Webber, Robert H. Blum, Caitlin D. Ryan, Laura Bendzick, Seonhui Shim, Ashley M. Yingst, Dejene M. Tufa, Michael R. Verneris, Dan S. Kaufman.
Blood. 2017
JM Lee, SH Lee, J-W Hwang, SJ Oh , B Kim , S Jung , S-h Shim , PW Lin , SB Lee , M-Y Cho , YJ Koh , SY Kim , S Ahn , J Lee , K-m Kim , KH Cheong , J Choi and K-A Kim.
Oncogene. 2016 February
Oh YM, Lee SB, Choi JH, Suh HY, Shim SH, Song YJ, Kim BG, Lee JM, Jeong YJ, Cheong KH, Song P H, Kim KA.
Scientific Report. 2014 May 15;4:4980
Shim SH, Hah JH, Cho SY, Kim TM, Koh YI, Kim DW, Heo DS, Sung MW. Korean Journal of Head & Neck Oncology.
2014 October v30 p43-52.
Kim DR, Park MY, Lee CS, Shim SH, Yoon HI, Lee JH, Sung MW, Kim YS, Lee CT.
Cancer Gene Ther. 2011 Jul;18(7):467-77
Shim SH, Lee CT, Hah JH, Lee JJ, Heo DS, Sung MW.
Tumour Biol. 2010 Dec;31(6):659-66
Shim SH, Hah JH, Hwang SY, Heo DS, Sung MW. Oncology Reports.
2010 Apr;23(4):1139-43
Oh JY, Park MY, Kim DR, Lee JH, Shim SH, Chung JH, Yoon HI, Lee JH, Sung MW, Kim YS, Lee CT.
Int J Mol Med. 2010 Mar;25(3):369-76.
Shim SH, Lee CT, Hah JH, Lee JJ, Park SW, Heo DS, Sung MW.
Cancer Science. 2009 Oct, 101(2):482-487.
Shim SH, Sung MW, Park SW, Heo DS.
Int J Mol Med. 2009 Jun;23(6):805-10.
Park SW, Sung MW, Heo DS, Inoue H, Shim SH, Kim KH.
Oncogene. 2005 Oct 6;24(44):6689-98.
U.S. 63/007,664
KR14-0130560, US20160090635A1
KR14-0163792, US20160144027A1
EP15150360, CN20150008065.5 KR14-0001799, US20150192588A1
KR13-0033874
KR13-0073820
PCT/KR2014/004672/ US20170233489A1
US14/023538 KR12-100649 EP13183787.4
Generation of Engraftable Hematopoietic Stem Cells From iPS/ES stem cells
Antitumor effect of tumor suppressor p53p18 chimeric protein with intracellular trafficking.
The 4th World Congress of International Federation of Head and Neck Oncologic Societies, Seoul, Korea.